Table 2.

Characteristics of secondary squamous cell carcinoma of head and neck in the survivors of hematopoietic stem cell transplantation for hematologic malignancies (comparing our series with series from literature review)

Study	N	Oral cGvHD %	Prior dysplasia %	Multifocal/ metachronous SCC%	Tongue primary %	Median time from HSCT (years)	Risk factors (% of patients with alcohol use/tobacco use and HPV positivity)	Treatment	Recurrence %
Mawardi et al. [6]	15	96	19	28	56	6	4/15/NR	Surgery alone 67%	44 at median of 17 months
Chung et al. [7]	7	100	NR	33	100	8	0/0/NR		33
Chen et al. [8]	6	100	NR	None	50	10	0/0/0	NR	None at median of 3 years
Our series	6	83	67	67	83	8	0/0/0	Surgery alone 83%	50
Janin et al. [9]	4	100	NR	NR	NR	5–22	0/0/NR	Surgery alone 100%	All died of recurrence by 1 year
Jaguar et al. [11]	2	100	NR	NRp	50	13 and 15 years	0/0/NR	Surgery and radiation	No recurrence at 2 years
Reddy et al. [12]	3	33	NR	NR	33	1.5 years, 8 years, and 15 years	0/0/NR	Surgery alone	33
Szeto et al. [13]	2	100	NR	NR	100	2 and 6 years	0/0/NR	Surgery alone	50

cGvHD chronic graft-versus-host disease; NR not reported