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. 2019 Jan 9;99(4):528–538. doi: 10.1038/s41374-018-0175-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Inhibition of neddylation reduces the severity of collagen-induced arthritis. a, b Time curve of body weight and arthritis score. c, d Visual inspection and X-ray analysis of affected hind limbs. e Pain score of affected paws. f Synovium volume detected by MRI of the knee joints. g–i Quantification analysis of TNF-α, IL-6, and IL-17A mRNA expression in the affected paws. *P < 0.05, **P < 0.01, ****P < 0.0001. P values were analyzed by two-way ANOVA in (a, b) and one-way ANOVA in (e–i)