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. 2019 Jan 9;99(4):528–538. doi: 10.1038/s41374-018-0175-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Inhibition of neddylation suppresses IL-17A-induced synovial cell proliferation. a–c Synovial cells were incubated with 100 ng/ml IL-17A with or without 100 nM MLN4924, and the proliferation was detected by scratch wound healing (a, b) and CCK8 assay (c). The red dotted line represents the area of the scratch at t = 0 h. The yellow dotted line represents the area of the scratch at t = 72 h.*P < 0.05, **P < 0.01, ****P < 0.001. P values were analyzed by two-way ANOVA in (b) and one-way ANOVA in (c)