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. 2019 Apr 2;63(1):97–107. doi: 10.1042/EBC20180061

Table 1. Summary of alternative histone acyl modifications.

Acyl group structure Properties HATs HDACs
graphic file with name ebc-63-ebc20180061-i1.jpg Hydrophobic p300/CBP [79,93], PCAF [112], GCN5 [93,113], MOF, HBO1, MOZ [114] SIRT1/2/3 [115]
graphic file with name ebc-63-ebc20180061-i2.jpg Hydrophobic p300/CBP [78,93], PCAF [93], GCN5 [93,113] SIRT1/2/3 [115]
graphic file with name ebc-63-ebc20180061-i3.jpg Hydrophobic p300/CBP [10], MOF [95] HDACs 1/2/3 [96,116–118], SIRT1/2/3 [119]
graphic file with name ebc-63-ebc20180061-i4.jpg Hydrophobic SIRT2 [83]
graphic file with name ebc-63-ebc20180061-i5.jpg Acidic SIRT5 [120]
graphic file with name ebc-63-ebc20180061-i6.jpg Acidic GCN5 [86] SIRT5 [120,121], SIRT7 [99]
graphic file with name ebc-63-ebc20180061-i7.jpg Acidic p300 [81] SIRT5 [81]
graphic file with name ebc-63-ebc20180061-i8.jpg Polar p300 [94], Tip60 [122] HDACs 1/2/3 (largely 2 and 3) [80,122]
graphic file with name ebc-63-ebc20180061-i9.jpg Polar p300 [85]

The chemical structures and properties of acyl groups and the enzymes which are currently known to catalyse the addition or removal of these from histones are shown.