Table 2.

Functions of sAC inferred from sAC knockout mouse phenotypes.

Male fertility; specifically, sperm capacitation and hyperactivated motility	Esposito et al. (2004), Farrell et al. (2008), Hess etal. (2005), Navarrete et al. (2016), Xie et al. (2006)
Regulation oflntraocular Pressure	Lee et al. (2011)
Glucose homeostasis; specifically, insulin response to bolus glucose challenge	Zippin et al. (2013)
Ciliary beat frequency in airway epithelial cells	Chen et al. (2014)
Transendothelial migration of leukocytes; specifically, sAC is required in endothelial cells to support leukocytes traversing the endothelial barrier	Watson et al. (2015)
Retinal ganglion cell growth and differentiation	Shaw et al. (2016)
Malignant progression was enhanced in chemically-induced carcinogenesis in skin in the absence of sAC	Ramos-Espiritu, Diaz, et al. (2016)