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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Vet Immunol Immunopathol. 2018 Jun 13;202:52–62. doi: 10.1016/j.vetimm.2018.06.011

Figure 2.

Figure 2

Lymphoid cell infiltration and COX-2 expression in feline OSCC by IHC analysis. A representative image of a feline OSCC shows T cell infiltration within neoplastic epithelium and stroma by staining with a feline cross-reactive CD3 monoclonal antibody and IHC analysis (200X magnification) (A). A representative image of T cell infiltration restricted predominantly to neoplastic stroma is shown (100X magnification) by CD3 IHC analysis (B). B cell follicle-like structure within neoplastic stroma is depicted by staining with a feline cross-reactive CD79a monoclonal antibody and IHC analysis (200X magnification) (C). Large numbers of B cells infiltrate neoplastic stroma in the absence of follicle-like structures as shown by CD79a IHC analysis (100X magnification) (D). Scattered Fox-P3+ cells infiltrate neoplastic stroma as shown by staining with a feline cross-reactive Fox-P3 monoclonal antibody and IHC analysis (200X magnification) (E). A representative image of variable COX-2 expression in neoplastic epithelium is shown by staining with a feline cross-reactive COX-2 monoclonal antibody and IHC analysis (200X magnification) (F). Insets within each image are a 400X magnification of a selected site within the parental image.