Table 1.
Hierarchical modeling of MC1R variants
| Model | Wildtype | Val60Leu | Val92Met | Arg151Cys | Ile155Thr | Arg160Trp | Arg163Gln | Asp294His | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Assumes that all variants have the same effects | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 2 | Regression coefficient with hair color in controls | 0 | −0.020 | −0.092 | 0.368 | 0.195 | 0.539 | 0.028 | 0.605 |
| 3 | Regression coefficient with skin color in controls | 0 | 0.149 | 0.083 | 0.310 | 0.140 | 0.250 | 0.026 | 0.428 |
| 4 | Regression coefficient with tanning ability in controls | 0 | 0.317 | 0.259 | 0.625 | 0.477 | 0.453 | 0.136 | 0.899 |
| 5 | Cell surface MC1R antibody binding | 0 | 0.772 | 0.004 | 1.505 | 1.911 | 1.537 | 0.411 | −0.378 |
| 6 | Cell surface MSH ligand binding | 0 | 1.234 | 0.126 | 1.966 | 3.808 | 2.137 | 0.648 | −0.466 |
| 7 | Kinetics, α-MSH Ki | 0 | 0.276 | 3.191 | −0.034 | 1,878 | 0.259 | 1.563 | 1.887 |
| 8 | Kinetics, NDP Ki | 0 | −0.084 | 0.069 | 0.808 | 0.313 | 0.425 | 0.468 | −0.166 |
| 9 | Maximum cAMP generation in response to MSH | 0 | 1.006 | 0.211 | 1.634 | 0.483 | 1.516 | −0.401 | 2.088 |
Parameters for models 5–9 were log transformed.