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. Author manuscript; available in PMC: 2019 May 30.
Published in final edited form as: J Am Chem Soc. 2018 May 18;140(21):6518–6521. doi: 10.1021/jacs.8b02100

Figure 2.

Figure 2.

Alternative conformational models of homodimeric PKS modules: (A) SAXS model of DEBS module 3 + TE;5 (B) cryo-EM model of module 5 of the pikromycin synthase.6 Docking domain (“coil”), blue; KS, green; KS-AT linker, cyan; AT, pink; KR, yellow; ACP, orange; TE, brown. The collinear domain organization is as shown in Figure 1. The two conformations differ primarily in the orientation of the AT and L domains relative to the KS.