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. 2019 Jan 29;169(1):151–166. doi: 10.1093/toxsci/kfz029

Figure 1.

Figure 1.

Virtual Mouse components and their organization. A, A virtual Mouse comprises a Liver, Mouse Body, as well as a space to contain Dose for simulating intraperitoneal dosing. B, An illustration of a sectioned hepatic lobule. Different shading illustrates idealized zonation. C, An illustration of a portion (only 16%) of one Monte Carlo-sampled Lobule. D, One Sinusoid Segment (SS) maps to a portion of a lobule, within one of the three illustrated Layers. E, An illustration of a multi-layered SS. F, Virtual Cell objects occupy 99% of the Endothelial Cell space and all of the Hepatocyte space.