Figure 2.

Intrahepatocyte events initiated by APAP. A, Within Control Mouse vHPCs, these events and activities may execute each simulation cycle. They do so independently in a pseudo-random order. Events marked with an asterisk are stochastic. Right side check marks designate features that are subject to Zonation. B, These five graphs show how particular features depend on Lobular location. Left side: the value assigned to vHPCs adjacent to the Portal Vein (PV) entrance. Right side: the value assigned to vHPCs adjacent to the central vein (CV). C, Within Test Mouse vHPCs, the Stressed and Necrosis-Triggered features replace Necrosis-Triggered in Control Mice. Initiation of Necrosis-Triggered is changed to initiation of Stressed (the Threshold value is unchanged). Information about the status of neighbors is used to determine when Necrosis-Triggered may be initiated. Damage mitigation and all other upstream features are unchanged from A.