Figure 9.

The progression of features characterizing APAP-induced hepatic injury. A, This spectrum depicts APAP-induced hepatic injury in vivo as a complex process. Stages of progression are typically identified by a characteristic feature or activity, including those listed. B, This sketch depicts simulated APAP-induced injury in Test Mice as a two-stage sequence. Stage 1 (Normal-to-Stressed) is the coarse grain biomimetic model mechanism described in Figure 2C. During Stage 2, each vHPC determines its ultimate fate by using acquired information about neighbor status and adhering to Figure 6 logic.