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. 2019 Apr 25;23:143. doi: 10.1186/s13054-019-2387-8

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Culprit pathogens’ distribution over the time (expressed as percentage of infective endocarditis case) and interrupted time series analysis. Intracellular germs include Coxiella Burnetii, Bartonella spp., Brucella spp., Chlamydia spp., Mycoplasma pneumoniae, Legionella pneumophila, Rickettsiae sp., Mycobacterium tuberculosis, and other Mycobacterium species, Francisella tularensis, Listeria monocytogenes, Nocardia spp.