. 2019 Apr 25;19:119. doi: 10.1186/s12877-019-1126-y

Table 5.

OR for use of each category of psychotropic drugs at one time-point given use of the same drug at the previous time point with covariates measured at the same previous time-point

Variable	Antipsychotics (N = 954)				Antidepressants (N = 954)
	Unadjusted		Adjusted		Unadjusted		Adjusted
	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value
Assessed at previous time-point
CDR-SoB	1.14 (1.04; 1.24)	0.005	1.04 (0.91; 1.19)	0.582⁴	1.13 (1.07; 1.19)	< 0.001	1.04 (0.96; 1.13)	0.346⁵
GMHR (Good/fairly good)	0.56 (0.26; 1.22)	0.145	1.08 (0.43; 2.73)	0.866⁹	0.91 (0.59; 1.40)	0.668	1.37 (0.84; 2.23)	0.214⁶
PSMS	1.17 (1.07; 1.28)	0.001	1.13 (0.99; 1.29)	0.057²	1.13 (1.07; 1.20)	< 0.001	1.10 (1.01; 1.19)	0.025 ³
NPI Agitation sub-syndrome	1.07 (1.00; 1.14)	0.049	1.03 (0.94; 1.13)	0.557⁵	1.05 (1.00; 1.10)	0.037	0.97 (0.91; 1.02)	0.248⁸
NPI Psychosis sub-syndrome	1.10 (0.97; 1.25)	0.148	0.98 (0.79; 1.22)	0.867¹⁰	1.12 (1.02; 1.23)	0.018	1.04 (0.93; 1.17)	0.482¹⁰
NPI Affective sub-syndrome	1.03 (0.96; 1.09)	0.410	1.01 (0.92; 1.11)	0.833⁸	1.09 (1.05; 1.13)	< 0.001	1.08 (1.03; 1.13)	0.001 ²
Married	1.46 (0.64; 3.30)	0.365	0.84 (0.30; 2.39)	0.748⁷	0.69 (0.40; 1.20)	0.186	0.71 (0.38; 1.33)	0.287⁷
Entry to NH	3.57 (1.11; 11.50)	0.033	1.67 (0.40; 7.01)	0.488⁶	3.54 (1.64; 7.68)	0.001	2.52 (1.02; 6.26)	0.047 ⁴
Assessed at baseline
Age	0.92 (0.86; 0.98)	0.016	0.91 (0.84; 0.99)	0.034 ¹	0.95 (0.91; 0.99)	0.021	0.93 (0.89; 0.97)	0.001 ¹
Males	2.42 (1.12; 5.22)	0.025	2.10 (0.80; 5.53)	0.133³	0.68 (0.39; 1.16)	0.153	0.74 (0.40; 1.35)	0.319⁹
	Anxiolytics (N = 954)				Sedatives (N = 954)
	Unadjusted		Adjusted		Unadjusted		Adjusted
	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value
Assessed at previous time-point
CDR-SoB	1.13 (1.06; 1.21)	< 0.001	1.05 (0.94; 1.17)	0.377⁴	1.05 (0.99; 1.11)	0.074	0.99 (0.92; 1.08)	0.849⁹
GMHR (Good/fairly good)	0.80 (0.43; 1.51)	0.493	1.05 (0.51; 2.13)	0.901⁹	0.64 (0.41; 0.98)	0.039	0.70 (0.44; 1.12)	0.137³
PSMS	1.15 (1.06; 1.24)	< 0.001	1.13 (1.01; 1.26)	0.031 ²	1.09 (1.03; 1.16)	0.002	1.08 (0.99; 1.17)	0.056²
NPI Agitation sub-syndrome	1.05 (0.99; 1.11)	0.089	0.98 (0.91; 1.06)	0.665⁸	1.02 (0.97; 1.07)	0.474	1.01 (0.95; 1.07)	0.813¹⁰
NPI Psychosis sub-syndrome	1.13 (1.01; 1.27)	0.029	1.06 (0.92; 1.22)	0.422⁶	1.01 (0.91; 1.12)	0.892	0.96 (0.85; 1.10)	0.576⁷
NPI Affective sub-syndrome	1.07 (1.02; 1.13)	0.003	1.04 (0.98; 1.10)	0.167³	1.03 (0.99; 1.07)	0.123	1.02 (0.98; 1.07)	0.367⁵
Married	0.91 (0.43; 1.93)	0.801	1.52 (0.65; 3.59)	0.337⁵	0.77 (0.45; 1.32)	0.336	0.77 (0.43; 1.40)	0.396⁴
Entry to NH	1.63 (0.50; 5.36)	0.420	0.67 (0.17; 2.60)	0.561⁷	1.29 (0.51; 3.23)	0.589	0.77 (0.28; 2.13)	0.608⁸
Assessed at baseline
Age	1.02 (0.96; 1.09)	0.438	1.00 (0.94; 1.07)	0.978¹⁰	1.07 (1.02; 1.12)	0.003	1.07 (1.02; 1.12)	0.005 ¹
Males	0.23 (0.08; 0.69)	0.009	0.18 (0.05; 0.61)	0.006 ¹	1.00 (0.61; 1.66)	0.988	1.17 (0.67; 2.06)	0.585⁶

CDR-SoB Clinical Dementia Rating – Sum of Boxes

GMHR General Medical Health Rating, PSMS Physical Self-Maintenance Scale, NPI Neuropsychiatric Inventory, NH Nursing Home