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Pharmacokinetic parameters of ceftolozane and tazobactam
| Parameter | Ceftolozane | Tazobactam | ||
|---|---|---|---|---|
| Pre-filter | Post-filter | Pre-filter | Post-filter | |
| Clearance (L/h) | 2.1 | 5.4 | 6.4 | 17.4 |
| Volume of distribution (L) | 53.9 | 97.5 | 108.9 | 194.2 |
| Half-life (h) | 17.9 | 12.6 | 11.9 | 7.8 |
| AUC (h mg/L) | 960 | 373 | 157 | 57.6 |
| Maximum concentration (mg/L) | 99 | 53 | 37 | 14.5 |
| Minimum concentration (mg/L) | 55.9 | 25.8 | 11.4 | 5.1 |
AUC area under the concentration-time curve
