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. 2019 Feb 28;9(6):1683–1697. doi: 10.7150/thno.30487

Figure 8.

Figure 8

Immunoregulatory effect of NMP-MSC derived from hiPSC on CD3+ T cells in vitro. A. T cells were cultured with or without NMP-MSC or BMSC for 3 days, and their proliferation and productions of TNF-α and IFN-γ were examined by flow cytometry. The data represent mean ± SEM of four independent experiments. *p<0.05, **p<0.01, ***p<0.001, and n.s. is non-significant. B. mRNA transcripts of proinflammatory cytokines (IL-6, IL-8, and CCL2) and anti-inflammatory mediators (PDL1, TSG6, and IDO) were analyzed by qRT-PCR in NMP-MSC and control BMSC that had been exposed to an inflammatory environment. The data represent mean ± SEM of three independent experiments. *p<0.05, **p<0.01, ***p<0.001, and n.s. is non-significant.