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. 2019 Feb 20;9(6):1523–1537. doi: 10.7150/thno.32461

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© Ivyspring International Publisher

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Overview of the time course and cellular sources of TSPO. (A) TSPO is expressed by Iba-1 positive microglia/macrophages four weeks after CPZ induction. Fusion images of GFAP and TSPO reveal that TSPO is mostly independent of GFAP at this disease stage. (B) Six weeks after CPZ the remaining microglia/macrophages further express TSPO. Fusion images indicate astrocytes as important source of TSPO. Arrows point to exemplary microglia and astrocytes expressing TSPO. Scale bar: 100 µm Abbreviations: CPZ, cuprizone; Iba-1, ionized calcium-binding adapter molecule 1; GFAP, Glial fibrillary acidic protein.