Figure 4.

In vivo PET/CT imaging in the orthotopic brain tumor model after injection of ⁶⁸Ga-DOTA-labeled CPP-gVLPs: (A) Decay-corrected whole-body planar coronal PET/CT images of the U87-MGLu tumor-bearing animal model at 1 h and 2 h postinjection of 6-8 MBq of ⁶⁸Ga-DOTA-labeled CPP-gVLPs through tail veins. (B) The distribution of major organ uptake assessed directly from tissue sampling was expressed as a percentage of the injected dose/gram of tissue (% ID/g) through tail veins. (C) Representative micro-PET-MR images of U87-MGLu brain tumor mice intratumorally injected (by CED) with ⁶⁸Ga-DOTA-labeled CPP-gVLPs at 1 h postinjection (top row) and 2 h postinjection (bottom row); the tumor is indicated by an arrow. (D) The distribution of major organ uptake assessed directly from tissue sampling was expressed as a percentage of the injected dose/gram of tissue (% ID/g) through CED (inset: the distribution of tumor and normal brain uptake at 1 and 2 h post-injection).