Figure 5.

Murine brain tumor imaged in vivo with modified gold-silica nanoparticles for PAI, MRI, and Raman spectroscopy for guided surgery. (A) Tumor-bearing mice were given IV injections of the particles and imaged axially in 2D both pre- and post-injection at 2 h (PA), 3 h (Raman), and 4 h (MRI). PA and Raman images were overlaid with MRI demonstrating clear tumor visualization and co-localization between techniques. (B) 3D construction of MR with segmented tumor (red: top), 3D PA overlay with MRI (green: middle), and overlay of segmented tumor, PA, and MRI (bottom). Adapted with permission from ¹¹⁰, copyright 2012 Nature Publishing Group.