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. 2019 Feb 23;10(6):1479–1488. doi: 10.7150/jca.29282

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Tukey Boxplot of AREG protein level in in WHO grade I-IV astrocytomas. (A) AREG protein expression calculated including signals intensity of all detected isoforms. GBM tissue showed significantly downregulated AREG level compared to grade II and grade III astrocytomas. (B) AREG protein expression calculated including signal intensity of only 1st (heaviest) isoform (~50 kDa) showed similar associations as combined intensity calculations. (C) AREG protein level measured according to signal intensity of only 2nd (middle) isoform (~45 kDa) showed downregulated AREG in glioblastoma compared grade II astrocytoma. (D) AREG protein expression quantified including signal intensity of only 3rd (lightest) isoform (~42 kDa) showed significantly lower AREG levels in glioblastoma as compared to grade II astrocytoma tissue. Asterisk: *p<0.05; **p<0.01; ***p<0.001; AI-AIII - WHO grade I-III astrocytoma, GBM - glioblastoma.