Table 3.

Multivariate Cox regression analysis of potential prognostic factors

Factor	HR 95% Cl	B	p-value
Astrocytoma WHO grade
grade II
grade III	1.367 (0.451 - 4.143)	0.313	0.581
grade IV (GBM)	9.292 (1.334 - 64.717)	2.229	0.024
Age (scale)	1.066 (1.009 - 1.126)	0.064	0.022
AREG mRNA level (scale)	1.038 (0.885 - 1.219)	0.038	0.645
AREG protein level (scale)	1.937 (0.958 - 3.917)	0.661	0.066
AREG methylation status (n=133)	2.043 (0.873 - 4.78)	0.714	0.100