Table 3.
Genotype Distributions of AURKA Gene Polymorphisms among 862 non-smokers.
| Variable | Controls (N=562) n (%) | Patients (N=300) n (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| rs1047972 | ||||
| CC | 434 (77.2%) | 224 (74.7%) | 1.000 (reference) | 1.000 (reference) |
| TC | 122 (21.7%) | 72 (24%) | 1.143 (0.820-1.595) | 1.167 (0.775-1.759) |
| TT | 6 (1.1%) | 4 (1.3%) | 1.292 (0.361-4.624) | 2.266 (0.493-10.414) |
| TC+TT | 128 (22.8%) | 76 (25.3%) | 1.150 (0.830-1.594) | 1.209 (0.810-1.805) |
| rs2273535 | ||||
| TT | 263 (46.8%) | 135 (45%) | 1.000 (reference) | 1.000 (reference) |
| AT | 239 (42.5%) | 132 (44%) | 1.076 (0.799-1.448) | 0.913 (0.638-1.306) |
| AA | 60 (10.7%) | 33 (11%) | 1.071 (0.668-1.719) | 0.808 (0.448-1.456) |
| AT+AA | 299 (53.2%) | 165 (55%) | 1.075 (0.811-1.424) | 0.892 (0.635-1.253) |
| rs2064863 | ||||
| TT | 382 (68%) | 215 (71.7%) | 1.000 (reference) | 1.000 (reference) |
| GT | 162 (28.8%) | 76 (25.3%) | 0.834 (0.605-1.147) | 0.669 (0.454-0.986) |
| GG | 18 (3.2%) | 9 (3%) | 0.888 (0.392-2.012) | 0.496 (0.180-1.364) |
| GT+GG | 180 (32%) | 85 (28.3%) | 0.839 (0.617-1.141) | 0.649 (0.447-0.944) |
| rs6024836 | ||||
| AA | 231 (41.1%) | 122 (40.7%) | 1.000 (reference) | 1.000 (reference) |
| AG | 254 (45.2%) | 145 (48.3%) | 1.081 (0.801-1.458) | 1.055 (0.735-1.515) |
| GG | 77 (13.7%) | 33 (11%) | 0.811 (0.511-1.289) | 0.715 (0.407-1.255) |
| AG+GG | 331 (58.9%) | 178 (59.3%) | 1.018 (0.766-1.354) | 0.975 (0.691-1.375) |
Bold font indicates statistical significance (p < 0.05). The odds ratio (OR) with their 95% confidence intervals were estimated by logistic regression models. The adjusted odds ratio (AOR) with their 95% confidence intervals were estimated by multiple logistic regression models after controlling for age and gender.