Table 5.
Distribution frequency of the clinical status and AURKA rs6024836 genotype frequencies in 431 UCC patients.
| AURKA (rs6024836) | ||||
|---|---|---|---|---|
| Variable | AA (%) (n=173) | AG+GG (%) (n=258) | OR (95% CI) | p value |
| Stage | ||||
| Non muscle invasive tumor (pTa-pT1) | 91 (52.6%) | 144 (55.8%) | 1.000 (reference) | |
| Muscle invasive tumor (pT2-pT4) | 82 (47.4%) | 114 (44.2%) | 0.879 (0.597-1.293) | 0.512 |
| Tumor T status | ||||
| Ta | 37 (21. 4%) | 53 (20.5%) | 1.000 (reference) | |
| T1-T4 | 136 (78.6%) | 205 (79.5%) | 1.052 (0.656-1.688) | 0.833 |
| Lymph node status | ||||
| N0 | 147 (85%) | 233 (90.3%) | 1.000 (reference) | |
| N1+N2 | 26 (15%) | 25 (9.7%) | 0.607 (0.337-1.091) | 0.095 |
| Metastasis | ||||
| M0 | 163 (94.2%) | 254 (98.4%) | 1.000 (reference) | |
| M1 | 10 (5.8%) | 4 (1.6%) | 0.257 (0.079-0.832) | 0.023 |
| Histopathologic grading | ||||
| Low grade | 19 (11%) | 34 (13.2%) | 1.000 (reference) | |
| High grade | 154 (89%) | 224 (86.8%) | 0.813 (0.447-1.478) | 0.497 |
Bold font indicates statistical significance (p < 0.05). The odds ratio (OR) with their 95% confidence intervals were estimated by logistic regression models.