Table 1.
Risk factors of non-metastasis disease
| Neuroendocrine carcinoma | Squamous cell carcinoma | Adenocarcinoma | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analyses | Multivariate analyses | Univariate analyses | Multivariate analyses | Univariate analyses | Multivariate analyses | |||||||||
| HR (95%CI) |
P- value |
HR (95%CI) |
P- value | HR (95%CI) |
P- value |
HR (95%CI) |
P- value |
HR (95%CI) |
P- value |
HR (95%CI) |
P- value |
|||
| Gender | ||||||||||||||
| Female | reference | reference | reference | reference | reference | reference | ||||||||
| Male | 1.07(0.65-1.75) | 0.79 | 1.16(0.50-2.70) | 0.73 | 1.01(0.94-1.09) | 0.69 | 1.01(0.94-1.09) | 0.70 | 0.82(0.75-0.89) | <0.01 | 0.92(0.84-1.00) | 0.04 | ||
| Age | ||||||||||||||
| <66 year-old | reference | reference | reference | reference | reference | reference | ||||||||
| >=66 year-old | 1.31(0.80-2.14) | 0.28 | 1.38(0.78-2.44) | 0.27 | 1.17(1.09-1.25) | <0.01 | 1.13(1.05-1.22) | <0.01 | 1.30(1.23-1.37) | <0.01 | 1.13(1.06-1.20) | <0.01 | ||
| Location | ||||||||||||||
| Upper third of esophagus | reference | reference | reference | reference | reference | reference | ||||||||
| Middle third of esophagus | 0.70(0.28-1.75) | 0.44 | 0.10(0.02-0.41) | <0.01 | 0.95(0.87-1.05) | 0.35 | 1.04(0.95-1.15) | 0.39 | 1.33(1.03-1.73) | 0.03 | 1.59(1.22-2.06) | <0.01 | ||
| Lower third of esophagus | 0.90(0.37-2.15) | 0.81 | 0.20(0.05-0.85) | 0.03 | 1.00(0.90-1.11) | 0.98 | 1.15(1.03-1.28) | 0.01 | 1.15(0.90-1.46) | 0.26 | 1.50(1.18-1.92) | <0.01 | ||
| Unspecific | 2.19(0.77-6.26) | 0.14 | 0.30(0.06-1.41) | 0.13 | 1.15(1.01-1.30) | 0.03 | 1.21(1.07-1.37) | <0.01 | 1.40(1.08-1.80) | 0.01 | 1.58(1.22-2.05) | <0.01 | ||
| Grade | ||||||||||||||
| I | reference | reference | reference | reference | reference | reference | ||||||||
| II | NA | NA | 1.03(0.86-1.23) | 0.75 | 0.96(0.80-1.15) | 0.68 | 1.08(0.93-1.25) | 0.32 | 1.07(0.92-1.25) | 0.35 | ||||
| III | NA | NA | 1.02(0.85-1.22) | 0.81 | 0.98(0.82-1.17) | 0.80 | 1.29(1.11-1.49) | <0.01 | 1.29(1.11-1.49) | <0.01 | ||||
| IV | 1.40(0.76-2.58) | 0.28 | 3.05(1.32-7.07) | 0.01 | 0.89(0.59-1.34) | 0.57 | 0.77(0.51-1.17) | 0.22 | 1.10(0.81-1.50) | 0.53 | 1.21(0.89-1.64) | 0.23 | ||
| Unspecific | 0.61(0.32-1.19) | 0.15 | 0.66(0.25-1.73) | 0.40 | 1.00(0.83-1.21) | 0.98 | 0.90(0.74-1.08) | 0.26 | 1.22(1.04-1.43) | 0.02 | 1.08(0.92-1.27) | 0.34 | ||
| Tumorsize | ||||||||||||||
| <2cm | reference | reference | reference | reference | reference | reference | ||||||||
| 2-3cm | 1.83(0.55-6.12) | 0.33 | 1.09(0.26-4.48) | 0.91 | 1.15(0.96-1.37) | 0.14 | 1.11(0.92-1.33) | 0.27 | 1.18(1.03-1.35) | 0.02 | 1.22(1.06-1.39) | 0.01 | ||
| 3-4cm | 2.04(0.59-7.14) | 0.26 | 1.97(0.42-9.13) | 0.39 | 1.23(1.04-1.46) | 0.02 | 1.16(0.98-1.39) | 0.09 | 1.18(1.04-1.35) | 0.01 | 1.15(1.00-1.31) | 0.05 | ||
| 4-5cm | 2.56(0.60-10.95) | 0.21 | 1.93(0.35-10.68) | 0.45 | 1.32(1.12-1.56) | <0.01 | 1.18(0.99-1.40) | 0.06 | 1.20(1.05-1.37) | 0.01 | 1.08(0.95-1.24) | 0.24 | ||
| 5-6cm | 3.75(0.97-14.50) | 0.06 | 3.64(0.76-17.38) | 0.11 | 1.34(1.12-1.60) | <0.01 | 1.16(0.96-1.39) | 0.12 | 1.29(1.12-1.49) | <0.01 | 1.18(1.02-1.37) | 0.03 | ||
| 6-7cm | 3.00(0.84-10.68) | 0.09 | 2.05(0.40-10.44) | 0.39 | 1.34(1.10-1.64) | <0.01 | 1.19(0.97-1.45) | 0.10 | 1.41(1.20-1.67) | <0.01 | 1.26(1.06-1.49) | 0.01 | ||
| 7-8cm | 4.00(0.92-17.35) | 0.06 | 1.86(0.31-11.25) | 0.50 | 1.45(1.17-1.79) | <0.01 | 1.26(1.02-1.57) | 0.04 | 1.39(1.16-1.66) | <0.01 | 1.23(1.03-1.48) | 0.02 | ||
| >8cm | 4.64(1.53-14.09) | 0.01 | 3.77(1.04-13.68) | 0.04 | 1.65(1.38-1.98) | <0.01 | 1.43(1.19-1.73) | 0.00 | 1.56(1.34-1.82) | <0.01 | 1.41(1.21-1.65) | <0.01 | ||
| Unspecific | 3.09(1.17-8.11) | 0.02 | 2.73(0.85-8.75) | 0.09 | 1.32(1.15-1.52) | <0.01 | 1.09(0.94-1.26) | 0.23 | 1.44(1.30-1.61) | <0.01 | 1.14(1.02-1.27) | 0.02 | ||
| Tstage | ||||||||||||||
| T0 | reference | reference | reference | reference | reference | reference | ||||||||
| T1 | NA | NA | 3.20(0.80-12.82) | 0.10 | 2.63(0.65-10.68) | 0.18 | NA | NA | ||||||
| T2 | 2.23(0.87-5.71) | 0.10 | 4.39(1.16-16.54) | 0.03 | 2.62(0.65-10.53) | 0.18 | 2.31(0.57-9.38) | 0.24 | 0.82(0.74-0.90) | <0.01 | 0.84(0.76-0.93) | <0.01 | ||
| T3 | 2.66(1.32-5.36) | 0.01 | 3.06(1.32-7.08) | 0.01 | 3.11(0.77-12.46) | 0.11 | 2.75(0.68-11.14) | 0.16 | 0.96(0.89-1.03) | 0.26 | 0.99(0.91-1.07) | 0.81 | ||
| T4 | 2.85(1.30-6.26) | 0.01 | 2.20(0.74-6.52) | 0.16 | 4.39(1.09-17.60) | 0.04 | 3.58(0.88-14.52) | 0.07 | 1.29(1.16-1.44) | <0.01 | 1.14(1.02-1.27) | 0.02 | ||
| Unspecific | 3.07(1.45-6.50) | <0.01 | 4.80(1.56-14.73) | 0.01 | 4.45(1.11-17.85) | 0.04 | 3.26(0.80-13.25) | 0.10 | 1.73(1.57-1.92) | <0.01 | 1.28(1.15-1.43) | <0.01 | ||
| Nstage | ||||||||||||||
| N0 | reference | reference | reference | reference | reference | reference | ||||||||
| N1 | 1.00(0.61-1.64) | 0.99 | 1.17(0.62-2.20) | 0.62 | 0.95(0.89-1.02) | 0.18 | 0.93(0.87-1.01) | 0.09 | 1.02(0.96-1.09) | 0.43 | 1.13(1.06-1.21) | <0.01 | ||
| N2 | 0.46(0.06-3.37) | 0.44 | 0.28(0.03-2.75) | 0.27 | 1.09(0.89-1.34) | 0.39 | 1.03(0.84-1.26) | 0.79 | 1.22(1.05-1.42) | 0.01 | 1.39(1.19-1.62) | <0.01 | ||
| Unspecific | 1.47(0.64-3.37) | 0.36 | 0.43(0.12-1.63) | 0.22 | 1.53(1.34-1.75) | <0.01 | 1.31(1.14-1.51) | <0.01 | 1.99(1.77-2.25) | <0.01 | 1.42(1.24-1.62) | <0.01 | ||
| Primary site surgery | ||||||||||||||
| Yes | 0.33(0.16-0.69) | <0.01 | 0.06(0.00-0.74) | 0.03 | 0.58(0.53-0.63) | <0.01 | 0.66(0.55-0.80) | <0.01 | 0.51(0.48-0.54) | <0.01 | 0.60(0.51-0.69) | <0.01 | ||
| No | reference | reference | reference | reference | reference | reference | ||||||||
| Lymph node dissection | ||||||||||||||
| Yes | 0.36(0.17-0.76) | 0.01 | 4.23(0.33-54.23) | 0.27 | 0.59(0.53-0.65) | <0.01 | 0.93(0.76-1.13) | 0.45 | 0.53(0.5-0.57) | <0.01 | 0.90(0.77-1.04) | 0.15 | ||
| No | reference | reference | reference | reference | reference | reference | ||||||||