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. 2019 Feb 23;10(6):1375–1384. doi: 10.7150/jca.29932

Figure 5.

Figure 5

SUZ12 inhibits the migration and invasion of HCC cells via inactivating the ERK1/2 signaling pathway. (A) Representative images of Transwell migration and invasion assays in SUZ12-silenced Hep3B and SMMC-7721 cells treated with SCH772984 or control (magnification: ×400). (B) The bar charts stood for the average number of migratory and invaded cells from five random microscopic fields. (C) Western blot analysis of P-ERK1/2, MMP9 and MMP2 proteins in SUZ12-silenced Hep3B and SMMC-7721 cells treated with SCH772984 or control. (D) The levels of the indicated proteins were quantified with gray value. The data represent the Mean ± SD, ***P<0.001, *P<0.05.