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. 2019 Feb 23;10(6):1409–1416. doi: 10.7150/jca.28659

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© Ivyspring International Publisher

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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The impact of sequential radiotherapy after nimotuzumab, paclitaxel, and cisplatin (TPN) combination treatment on the survival of esophageal squamous cell carcinoma patients. In all, 23 patients with local-regional ESCC received sequential radical radiation treatment (RT) after TPN treatment. Six patients with metastatic disease and 3 patients with recurrent disease but with oligo-metastases (limited local lymph node metastases) after esophagectomy also received palliative RT after TPN treatment. Compared with those who did not received RT, patients who received sequential RT exhibited longer median PFS (PFS16.4±5.7 vs 6.4±1.8 months, p=0.064) (A) and OS (26.2±6.5 vs 11.5±2.6 months, p=0.036) (B).