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RNA-sequencing in tumors of PDX-KITK642E after 28 days of treatment with imatinib (n = 3) and ponatinib (n = 3). (A) Heatmap of differential expressed genes between the imatinib-treated group and ponatinib-treated group. (B) KEGG analysis showed that the ECM-receptor interaction pathway was the most significantly downregulated pathway in ponatinib-treated tumors compared with imatinib-treated tumors.
