Table 2.
Cardiac function evaluated by echocardiography
| Sham (n=5) |
CKD (n=5) |
CKD+Exo/ ctrl (n=5) |
CKD+Exo/ miR-26a (n=5) |
|
|---|---|---|---|---|
| Heart weight (g) | 0.14±0.01 | 0.17±0.03 | 0.18±0.04 | 0.15±0.01 |
| Heart/Body weight | 5.78±0.51 | 8.72±0.86# | 8.78±0.71# | 6.55±0.49* |
| IVS-d (mm) | 0.51±0.0 | 0.48±0.0 | 0.49±0.0 | 0.48±0.0 |
| LVEDD (mm) | 3.71±0.1 | 4.01±0.0# | 4.11±0.0# | 3.83±0.0* |
| FW-D (mm) | 0.50±0.0 | 0.47±0.0 | 0.46±0.0 | 0.48±0.0 |
| IVS-s (mm) | 1.05±0.0 | 1.10±0.0 | 1.09±0.0 | 1.07±0.0 |
| LVESD (mm) | 2.68±0.1 | 3.19±0.1# | 3.23±0.2# | 2.86±0.1* |
| FW-S (mm) | 0.74±0.0 | 0.73±0.0 | 0.74±0.0 | 0.74±0.0 |
| LV Vol-d | 58.94±3.1 | 70.66±1.6# | 71.33±1.8# | 62.33±2.5* |
| LV Vol-s | 26.98±2.3 | 40.97±2.3# | 41.58±2.7# | 32.69±2.1* |
| %EF | 54.59±2.2 | 42.20±2.2# | 41.78±2.1# | 49.87±2.4* |
| FS | 27.85±1.5 | 20.49±1.2# | 19.55±1.1# | 25.61±1.4* |
| LV Mass | 56.79±2.7 | 60.84±1.7 | 61.0±1.8 | 57.89±2.6 |
#P < 0.05 vs. Sham; *P < 0.05 vs. CKD+Exo-ctrl; IVS-d: interventricular septum diameter; LVEDD: left ventricular end-diastolic diameter; FW-D: free wall in diastole; IVS-s: interventricular septum in systole; LVESD: left ventricular end-systolic diameter; FW-S: free wall in systole; LV Vol-d: left ventricular volume in diastole; LV Vol-s: left ventricular volume in systole; %EF: % ejection fraction; FS: fractional shortening; LV Mass: left ventricular mass