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. 2019 Apr 11;124(8):1172–1183. doi: 10.1161/CIRCRESAHA.118.314505

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© 2019 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Effects of electrical pacing on TTN-GFP human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) contractile parameters assessed by SarcTrack. A, Histogram showing the number of observations as a function of contraction time in paced (gray, 1 Hz stimulation) and unpaced (green) hiPSC-CMs. B, Relaxation time as a function of pacing status. C, Contracted sarcomere length (SL) as a function of pacing. D, Relaxed SL as a function of pacing. E, Sarcomere shortening as a function of pacing. F, Beat rate as a function of pacing. TTN-GFP hiPSC-CMs were studied at day 30 of differentiation. Observation denotes the mean data from one field of view (≈200 sarcomeres). Histograms were generated from 122 unpaced and 116-paced fields of views. Each histogram was fitted with a single Gaussian distribution and the mean and SEM is indicated.