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. 2019 Apr 11;124(8):1228–1239. doi: 10.1161/CIRCRESAHA.118.314600

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© 2019 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 7. — Cytoplasmic and myofilament localized Ca²⁺ transients with adenovirally transduced cTnT R92Q and cTnI R145G. Averaged Ca²⁺ transients of 0.5 Hz paced Guinea pig cardiomyocytes (GPCMs) transduced with RGECO (A and B) or RGECO-TnI (Troponin I)/RGECO-TnT (Troponin T; C and D) was used to compare Ca²⁺ transient effects between GPCMs transduced with either WT cTnT/cTnT R92Q (A and C), or WT cTnI/cTnI R145G (B and D). Peak amplitude ratio (E) and Δvalues for time to 50% binding (On; F) and 50% release (Off; G) are plotted including significance and labeled cytoplasmic (c) and myofilament (m; n=94–124 cells from n=3 isolations). Error bars are SD, **P<0.01 and ***P<0.001 using a Mann-Whitney test comparing wild-type (WT) troponin to mutant troponin transduced cells.