Table 1.

Overview of the advantages and disadvantages of the PFS for intravitreal drug delivery

Proposed advantages/disadvantages	Characterization of evidence
Reduced injection time	Strongly supportive
Reduction in endophthalmitis risk	Theoretical
Reduction in intraocular air bubbles and silicone oil droplets	Theoretical, of possible clinical significance
Accuracy and precision of intravitreal ranibizumab doses	Supportive
Disadvantages of a sterile syringe/drug assembly	Theoretical

Abbreviation: PFS, prefilled syringe.