for the main comparison.

Etoricoxib compared with placebo for acute postoperative pain
Patient or population: adults with moderate or severe acute postoperative pain Settings: community or hospital Intervention: etoricoxib 120 mg Comparison: placebo
Outcomes	Probable outcome with		Relative effect and NNT or NNH (95% CI)	No of studies, events	Quality of the evidence (GRADE)	Comments
	comparator	intervention
At least 50% of maximum pain relief over 4 to 6 hours	120 in 1000	660 in 1000	RR 5.6 (4.0 to 7.8) NNT 1.9 (1.7 to 2.1)	6 studies 789 participants 366 events	High	Adequate numbers of studies, participants and events. Consistency across studies
Participants with at least 1 adverse event	360 in 1000	330 in 1000	RR 0.93 (0.74 to 1.2) NNH not calculated	5 studies 643 participants 219 events	Moderate	Moderate numbers of studies, participants and events. Consistency across studies. Single dose studies may not reflect clinical practice
Participants with a serious adverse event	No serious adverse events				Low	Studies underpowered to detect rare events
Deaths	No deaths				Low	Studies underpowered to detect rare events
CI: Confidence interval; NNH: number needed to treat for harm; NNT: number needed to treat for benefit; RR: Risk Ratio
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.