Daniels 2011.

Methods	RCT, DB, 4 oral doses over 24 hours (single active dose of etoricoxib), 5 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90 mins, hourly up to 8 hours, then at 10, 12, 20, and 24 hours
Participants	Impacted third molar extraction N = 588 M = 248, F = 340 Mean age 22 years
Interventions	Etoricoxib 90 mg, n = 191 Etoricoxib 120 mg, n = 97 Ibuprofen 600 mg (6‐hourly), n = 192 Paracetamol + codeine 600/60 mg (6‐hourly), n = 62 Placebo, n = 46
Outcomes	PI: standard 4‐point scale PR: standard 5‐point scale PGE: standard 5‐point scale Time to use of rescue medication Number of participants using rescue medication Number of participants reporting adverse events and serious adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB1, W1 Rescue medication available for inadequate response (no details of timing)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Low risk	Medication provided in numbered containers; participant allocated to next number in sequence
Blinding (performance bias and detection bias) All outcomes	Unclear risk	"in house blinding conditions". "Investigator, study nurse, patients, monitors, laboratory personnel remained blinded throughout the study".
Incomplete outcome data (attrition bias) All outcomes	Low risk	Participants accounted for; analysis appropriate for relevant time interval
Other bias	High risk	Small treatment group size (97 to 192 active, 46 placebo participants)