Malmstrom 2004a.

Methods	RCT, DB, single oral dose, 6 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90 mins then at 2, 3, 4, 5, 6, 7, 8, 12, and 24 hours
Participants	Impacted third molar extraction N = 398 M = 147, F = 251 Mean age 21 years
Interventions	Etoricoxib 60 mg, n = 75 Etoricoxib 120 mg, n = 76 Etoricoxib 180 mg, n = 74 Etoricoxib 240 mg, n = 76 Ibuprofen 400 mg, n = 48 Placebo, n = 49
Outcomes	PI: standard 4‐point scale PR: standard 5‐point scale PGE: standard 5‐point scale Time to use of rescue medication Number of participants using rescue medication Number of participants reporting adverse events and serious adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1 Participants asked to refrain from using rescue medication for 90 mins
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"computer‐generated allocation schedule"
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐dummy method. "matching placebo tablet" for both active treatments
Incomplete outcome data (attrition bias) All outcomes	Low risk	Participants accounted for; analysis appropriate for relevant time interval
Other bias	Unclear risk	Small treatment group size (48 to 76 participants)