Rasmussen 2005.

Methods	RCT, DB, single and multiple oral doses, 3 parallel groups Medication administered when baseline pain reached a moderate to severe intensity, after withdrawal of patient controlled analgesia. Patient assessment at 0, 30, 60, 90, 120 mins, then hourly to 8 hours, then at 10, 12, 20, and 24 hours for the single‐dose study
Participants	Orthopaedic surgery (40% hip, 60% knee) N = 228 M = 90, F = 138 Mean age 65 years
Interventions	Etoricoxib 120 mg, n = 80 Naproxen sodium (CR) 1100 mg, n = 73 Placebo, n = 75
Outcomes	PR: standard 5‐point scale PGE: standard 5‐point scale Time to use of rescue medication Number of participants using rescue medication Number of participants reporting adverse events and serious adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1 Participants asked to refrain from using rescue medication for 90 mins
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"computer‐generated allocation schedule"
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Double‐dummy method. "matching placebo tablet" for both active treatments
Incomplete outcome data (attrition bias) All outcomes	Low risk	Participants accounted for; analysis appropriate for relevant time interval
Other bias	Unclear risk	Small treatment group size (73 to 80 participants)

DB ‐ double‐blind; F ‐ female; M ‐ male; N ‐ total number in trial; n ‐ number in treatment arm; PI ‐ pain intensity; PR ‐ pain relief; PGE ‐ patient global evaluation; R ‐ randomised; RCT ‐ randomised controlled trial; W ‐ withdrawals