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. 2019 Jan 10;4(1):e122742. doi: 10.1172/jci.insight.122742

Figure 5. Oxidized LDL but not estrogen regulates lipid abundance in macrophages.

Figure 5

(A) Female human PBDMs were differentiated into M0 macrophages, treated with oxLDL, and exposed to selected concentrations of estradiol (E2) as in Figure 4. (A) Representative images of Oil Red O staining obtained at the end of the incubation with E2. Scale bar: 100 μm. (B and C) Quantification of Oil Red O staining from all samples; n = 4 per condition. Statistical significance for B was determined using a Mann-Whitney test and for C was determined using ANOVA. The graphs show box and whisker plots with Tukey’s whiskers; the horizontal lines of boxes represent the 25th percentile, the median, and the 75% percentile. (D) Summary model of estrogen-mediated protection from arterial stiffening and atherosclerosis.