Table 3.
Reporting of non-adherence by length of intervention, randomised arm and level of adherence.
| One-off | Short term | Long term | Total | |
|---|---|---|---|---|
| Reporting of any non-adherence, n (%) | 5 (100) | 35 (100) | 83 (100) | 123 (100) |
| Non-adherence reported in both active and control groups | - | 4 (11.4) | 16 (19.3) | 20 (16.2) |
| Non-adherence reported in active group only | 2 (40.0) | 15 (42.9) | 19 (22.9) | 36 (29.3) |
| Non-adherence reported in control group only | - | - | - | - |
| Full adherence reported | - | 1 (2.9) | 4 (4.8) | 5 (4.1) |
| Not reported | 3 (60.0) | 11 (31.4) | 36 (43.4) | 50 (40.6) |
| Unclear | - | 4 (11.4) | 8 (9.6) | 12 (9.8) |
| Trials with adherence at cluster level | 2 (100) | 21 (100) | 42 (100) | 65 (100) |
| Non-adherence reported in both active and control groups | - | - | 1 (2.4) | 1 (1.5) |
| Non-adherence reported in active group only | - | 9 (42.9) | 5 (11.9) | 14 (21.5) |
| Non-adherence reported in control group only | - | - | - | - |
| Full adherence reported | - | 1 (4.7) | 3 (7.1) | 4 (6.2) |
| Not reported | 2 (100) | 9 (42.9) | 29 (69.1) | 40 (61.6) |
| Unclear | - | 2 (9.5) | 4 (9.5) | 6 (9.2) |
| Trials with adherence at individual level | 3 (100) | 14 (100) | 41 (100) | 58 (100) |
| Non-adherence reported in both active and control groups | - | 4 (28.6) | 15 (36.6) | 19 (32.8) |
| Non-adherence reported in active group only | 2 (66.7) | 6 (42.9) | 14 (34.1) | 22 (38.0) |
| Non-adherence reported in control group only | - | - | - | - |
| Full adherence reported | - | - | 1 (2.4) | 1 (1.7) |
| Not reported | 1 (33.3) | 2 (14.3) | 7 (17.1) | 10 (17.2) |
| Unclear | - | 2 (14.3) | 4 (9.8) | 6 (10.3) |
| Percentage of non-adherence at cluster levela | ||||
| Total number of trials reporting non-adherence, n (%) | - | 9 (100) | 6 (100) | 15 (100) |
| Trials reporting % of non-adherence in active group, n (%) | - | 2 (22.2) | 3 (50.0) | 5 (33.3) |
| Median % of non-adherence in active groupb | - | 37.4 (30–44.8) | 50 (33–80) | 44.8 (33–50) |
| Percentage of non-adherence at individual level | ||||
| Total number of trials reporting non-adherence, n (%) | 2 (100) | 10 (100) | 29 (100) | 41 (100) |
| Trials reporting % of non-adherence in active group, n (%) | 2 (100) | 7 (70.0) | 21 (72.4) | 30 (73.2) |
| Median % of non-adherence in active groupb | 16.5 (0.5–32.4) | 13.7 (5.3–25) | 15 (10–20) | 15 (9–24) |
| Total number of trials reporting non-adherence, n (%) | 2 (100) | 10 (100) | 29 (100) | 41 (100) |
| Trials reporting % of non-adherence in control group, n (%) | - | 3 (30.0) | 11 (37.9) | 14 (34.1) |
| Median % of non-adherence in control groupb | - | 8.1 (1.7–32) | 8.2 (3.4–20) | 8.2 (3.4–20) |
| Total number of trials, n (%) | 5 (100) | 35 (100) | 83 (100) | 123 (100) |
| Flow chart with adherence information | 1 (20.0) | 4 (11.4) | 6 (7.2) | 11 (8.9) |
| Flow chart without adherence information | 1 (20.0) | 19 (54.3) | 65 (78.3) | 85 (69.1) |
| No flow char | 3 (60.0) | 12 (34.3) | 12 (14.5) | 27 (22.0) |
| Adherence type, n (%)c | 2 (100) | 20 (100) | 39 (100) | 61 (100) |
| Binary adherence | 2 (100) | 14 (70.0) | 28 (71.8) | 44 (72.1) |
| Continuous adherence | - | 2 (10.0) | 3 (7.7) | 5 (8.2) |
| Unclear | - | 4 (20.0) | 8 (20.5) | 12 (19.7) |
| Trials using adherence-adjusted methods, n (%) | 1 (100) | 4 (100) | 14 (100) | 19 (100) |
| Per protocol | 1 (100) | 4 (100) | 10 (71.4) | 15 (78.9) |
| As treated | - | - | 4 (28.6) | 4 (21.1) |
a
No report provided non-adherence % at cluster level in the control group.
b
Numbers in brackets are the 1st and 3rd quartiles.
c
Total number of trials reporting non-adherence or full adherence.