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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: Nature. 2018 Jul 9;559(7714):400–404. doi: 10.1038/s41586-018-0317-6

Figure 2. Acquisition of specific recurrent AML mutations by healthy individuals at young age is associated with progression to AML.

Figure 2

a, Relative frequency of mutations in the indicated genes according to age group for pre-AMLs (red) and controls (blue). b, Proportion of pre-AML cases and controls harbouring ARCH-PD mutations in recurrently mutated genes. Asterisks (*) indicate P<0.05 (Fisher’s exact test with Bonferroni multiple testing correction). c, Plot showing the cumulative frequency of recurrent AML mutations (reported in >5 specimens in COSMIC) in pre-AML cases and controls. ARCH-PD mutations are ranked from left to right along the x-axis from low to high recurrence. d, VAF of recurrent mutations in cases and controls. Low, intermediate and highly recurrent COSMIC mutations are defined as those reported in 5-19 samples, 20-300 samples and >300 samples, respectively. Box plots indicate median, first and third quartiles and 1.5 x interquartile range. P-values were calculated by two-sided Wilcoxon rank sum test with Bonferroni multiple testing correction. All panels show data for n=800 unique individuals.