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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: Nature. 2018 Jul 9;559(7714):400–404. doi: 10.1038/s41586-018-0317-6

Extended Data Figure 3. Performance of combined model in predicting AML progression.

Extended Data Figure 3

a, Receiver operating characteristic (ROC) curve for prediction of AML development using model 1 (see Methods). The red dot indicates the point on the curve with the highest positive predictive value (PPV) with sensitivity of 41.9% and specificity of 95.7%. b, Kaplan-Meier estimates of time to AML diagnosis for individuals predicted to develop AML (red) and not develop AML (blue) by model 1 (HR = 10.38, P 4.2e-10 ,Wald test) and c) model 2 (HR = 10.75, P = 1.75e-08, Wald test), from the point of enrolment until the end of follow-up to the EPIC study.