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. 2016 Apr 20;2016(4):CD008541. doi: 10.1002/14651858.CD008541.pub3

Comparison 1. Sumatriptan plus naproxen versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Pain‐free at 2 h 12   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1.1 Mild baseline pain 8 3395 Risk Ratio (M‐H, Fixed, 95% CI) 2.76 [2.43, 3.13]
1.1.2 Moderate/severe baseline pain 4 2596 Risk Ratio (M‐H, Fixed, 95% CI) 3.65 [2.97, 4.49]
1.2 Headache relief at 2 h 4   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.2.1 Moderate/severe baseline pain 4 2596 Risk Ratio (M‐H, Fixed, 95% CI) 2.16 [1.95, 2.39]
1.3 24‐h sustained pain‐free 12   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.3.1 Mild baseline pain 8 3396 Risk Ratio (M‐H, Fixed, 95% CI) 3.04 [2.59, 3.56]
1.3.2 Moderate/severe baseline pain 4 2596 Risk Ratio (M‐H, Fixed, 95% CI) 3.43 [2.69, 4.36]
1.4 24‐h sustained headache relief 4   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.4.1 Moderate/severe baseline pain 4 2596 Risk Ratio (M‐H, Fixed, 95% CI) 2.61 [2.27, 2.99]
1.5 Any adverse event 10 5616 Risk Ratio (M‐H, Fixed, 95% CI) 1.76 [1.53, 2.03]
1.5.1 Mild baseline pain 6 2823 Risk Ratio (M‐H, Fixed, 95% CI) 1.47 [1.16, 1.86]
1.5.2 Moderate/severe baseline pain 4 2793 Risk Ratio (M‐H, Fixed, 95% CI) 1.97 [1.64, 2.37]
1.6 Rescue medication 12 5565 Risk Ratio (M‐H, Fixed, 95% CI) 0.45 [0.41, 0.48]
1.6.1 Mild baseline pain 8 3396 Risk Ratio (M‐H, Fixed, 95% CI) 0.42 [0.38, 0.47]
1.6.2 Moderate/severe baseline pain 4 2169 Risk Ratio (M‐H, Fixed, 95% CI) 0.47 [0.42, 0.53]
1.7 Relief of associated symptoms at 2 h 8   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.7.1 Nausea 8 1705 Risk Ratio (M‐H, Fixed, 95% CI) 3.47 [2.79, 4.32]
1.7.2 Photophobia 8 3127 Risk Ratio (M‐H, Fixed, 95% CI) 2.77 [2.44, 3.13]
1.7.3 Phonophobia 8 2856 Risk Ratio (M‐H, Fixed, 95% CI) 2.63 [2.33, 2.97]
1.8 Relief of functional disability at 2 h 5   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.8.1 Mild baseline pain 2 981 Risk Ratio (M‐H, Fixed, 95% CI) 2.91 [2.29, 3.72]
1.8.2 Moderate/severe baseline pain 3 1984 Risk Ratio (M‐H, Fixed, 95% CI) 3.36 [2.63, 4.29]