Comparison 2. Sumatriptan plus naproxen versus sumatriptan alone.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Pain‐free at 2 h	3	1925	Risk Ratio (M‐H, Fixed, 95% CI)	1.42 [1.23, 1.65]
2.2 Headache relief at 2 h	3	1925	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [1.11, 1.29]
2.3 24‐h sustained pain‐free	3	1925	Risk Ratio (M‐H, Fixed, 95% CI)	1.70 [1.41, 2.06]
2.4 24‐h sustained headache relief	3	1925	Risk Ratio (M‐H, Fixed, 95% CI)	1.39 [1.24, 1.55]
2.5 Any adverse event	3	1952	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.86, 1.16]
2.6 Rescue medication	3	1925	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.58, 0.76]
2.7 Relief of associated symptoms at 2 h	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.7.1 Nausea	2	718	Risk Ratio (M‐H, Fixed, 95% CI)	1.51 [1.21, 1.87]
2.7.2 Photophobia	2	1186	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [1.04, 1.39]
2.7.3 Phonophobia	2	1146	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [1.10, 1.45]
2.8 Relief of functional disability at 2 h	2	1354	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [1.18, 1.69]