Comparison 3. Sumatriptan plus naproxen versus naproxen alone.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Pain‐free at 2 h	3	1944	Risk Ratio (M‐H, Fixed, 95% CI)	2.03 [1.71, 2.40]
3.2 Headache relief at 2 h	3	1944	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [1.30, 1.54]
3.3 24‐h sustained pain‐free	3	1944	Risk Ratio (M‐H, Fixed, 95% CI)	2.25 [1.82, 2.78]
3.4 24‐h sustained headache relief	3	1944	Risk Ratio (M‐H, Fixed, 95% CI)	1.64 [1.45, 1.85]
3.5 Any adverse event	3	1970	Risk Ratio (M‐H, Fixed, 95% CI)	1.77 [1.47, 2.13]
3.6 Rescue medication	3	1944	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.54, 0.70]
3.7 Relief of associated symptoms at 2 h	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.7.1 Nausea	2	726	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.90, 1.32]
3.7.2 Photophobia	2	1176	Risk Ratio (M‐H, Fixed, 95% CI)	1.39 [1.19, 1.62]
3.7.3 Phonophobia	2	1135	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [1.28, 1.72]
3.8 Relief of functional disability at 2 h	2	1352	Risk Ratio (M‐H, Fixed, 95% CI)	1.63 [1.35, 1.97]