Summary of results: complete relief of functional disability at two hours | |||||||
Baseline pain | Studies | Attacks treated | Treatment (%) | Comparator (%) | Risk ratio (95% CI) | NNT (95% CI) | |
Sumatriptan plus naproxen 85/500 mg vs placebo | mild | 2 | 981 | 42 | 14 | 2.9 (2.3 to 3.7) | 3.7 (3.1 to 4.6)) |
Sumatriptan plus naproxen 85/500 mg vs placebo | ≥ mod | 3 | 1984 | 25 | 7.3 | 3.4 (2.6 to 4.3) | 5.8 (4.9 to 7.0) |
Sumatriptan plus naproxen 85/500 mg vs sumatriptan 85 mg | ≥ mod | 2 | 1354 | 32 | 23 | 1.4 (1.2 to 1.7) | 11 (7.1 to 21) |
Sumatriptan plus naproxen 85/500 mg vs naproxen 500 mg | ≥ mod | 2 | 1352 | 32 | 20 | 1.6 (1.4 to 2.0) | 8.0 (5.9 to 13) |
CI: confidence interval; mod: moderate; NNT: number needed to treat for an additional beneficial outcome. |