Summary of results: Pain‐free and headache relief
	Baseline pain	Studies	Attacks treated	Treatment (%)	Placebo or comparator (%)	Risk ratio (95% CI)	NNT (95% CI)
Pain‐free at 2 h
Sumatriptan plus naproxen 85/500 mg vs placebo	mild	8	3395	50	18	2.8 (2.4 to 3.1)	3.1 (2.9 to 3.5)
Sumatriptan plus naproxen 50‐85/500 mg vs placebo	≥ mod	4	2596	28	7.7	3.7 (3.0 to 4.5)	4.9 (4.3 to 5.7)
Sumatriptan plus naproxen 85/500 mg vs placebo	≥ mod	3	2105	27	8.1	3.3 (2.6 to 4.1)	5.4 (4.6 to 6.5)
Sumatriptan plus naproxen 50‐85/500 mg vs sumatriptan 50‐85 mg	≥ mod	3	1925	32	23	1.4 (1.2 to 1.7)	10 (7.4 to 18)
Sumatriptan plus naproxen 50‐85/500 mg vs naproxen 500 mg	≥ mod	3	1944	32	16	2.0 (1.7 to 2.4)	6.1 (5.0 to 7.9)
Headache relief at 2 h
Sumatriptan plus naproxen 50‐85/500 mg vs placebo	≥ mod	4	2596	58	27	2.2 (2.0 to 2.4)	3.2 (2.9 to 3.6)
Sumatriptan plus naproxen 85/500 mg vs placebo	≥ mod	3	2105	57	27	2.1 (1.9 to 2.4)	3.4 (3.0 to 3.9)
Sumatriptan plus naproxen 50‐85/500 mg vs sumatriptan 50‐85 mg	≥ mod	3	1925	62	52	1.2 (1.1 to 1.3)	9.8 (6.8 to 17)
Sumatriptan plus naproxen 50‐85/500 mg vs naproxen 500 mg	≥ mod	3	1944	62	44	1.4 (1.3 to 1.5)	5.5 (4.4 to 7.2)
Sustained pain‐free during the 24 h post dose
Sumatriptan plus naproxen 85/500 mg vs placebo	mild	8	3396	37	12	3.0 (2.6 to 3.6)	4.1 (3.7 to 4.6)
Sumatriptan plus naproxen 50‐85/500 mg vs placebo	≥ mod	4	2596	20	6	3.4 (2.7 to 4.4)	7.0 (5.9 to 8.5)
Sumatriptan plus naproxen 85/500 mg vs placebo	≥ mod	3	2005	19	6	3.1 (2.4 to 4.0)	7.7 (6.4 to 9.8)
Sumatriptan plus naproxen 50‐85/500 mg vs sumatriptan 50‐85 mg	≥ mod	3	1925	24	14	1.7 (1.4 to 2.1)	10 (7.4 to 15)
Sumatriptan plus naproxen 50‐85/500 mg vs naproxen 500 mg	≥ mod	3	1944	24	11	2.3 (1.8 to 2.8)	7.4 (6.0 to 9.9)
Sustained headache relief during the 24 h post dose
Sumatriptan plus naproxen 50‐85/500 mg vs placebo	≥ mod	4	2596	43	16	2.6 (2.3 to 3.0)	3.8 (3.4 to 4.3)
Sumatriptan plus naproxen 85/500 mg vs placebo	≥ mod	3	2107	42	16	2.6 (2.2 to 3.0)	3.9 (3.4 to 4.5)
Sumatriptan plus naproxen 50‐85/500 mg vs sumatriptan 50‐85 mg	≥ mod	3	1925	46	33	1.4 (1.2 to 1.6)	7.9 (5.9 to 12)
Sumatriptan plus naproxen 50‐85/500 mg vs naproxen 500 mg	≥ mod	3	1944	46	28	1.6 (1.5 to 1.9)	5.6 (4.5 to 7.4)