Mathew 2009 Study 2.

Study characteristics
Methods	Multicentre, R, DB, PC, cross‐over. Single dose to treat single attack. Washout between attacks ≥ 1 week Medication taken when PI mild and within 1 h of onset Assessments at 0, 0.5, 1, 1.5, 2, 4, 24, 48 h
Participants	Migraine ± aura (IHS 2004), aged 18 to 65 years, poor response to triptans with short half‐life. History: frequency of 1 to 8 per month, < 15 headache days monthly. Untreated severity ≥ mild Excluded: uncontrolled hypertension, cardio‐ or cerebrovascular disease N = 137 (131 for efficacy) F = 93% Mean age 40 years 27% without aura
Interventions	Sumatriptan 85 mg plus naproxen 500 mg, n = 134 Placebo, n = 133 Rescue medication allowed after 2 h if necessary (not specified)
Outcomes	Pain‐free at 2 h 24‐h sustained pain‐free Presence and relief of associated symptoms at 2 h Use of rescue medication AEs Withdrawals
Notes	Oxford Quality Score: R1, DB1, W1 Total = 3
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	Drop‐outs described
Study size	Unclear risk	50 to 200 participants per treatment arm