Study ID	Treatment	HR 1 h	HR 2 h	PF 2 h	SHR 24 h	SPF 24 h	Use of rescue medication
Brandes 2007 Study 1	(1) suma/naprox 85/500 mg, n = 370 (2) suma 85 mg, n = 365 (3) naprox 500 mg, n = 361 (4) placebo, n = 365	No data	(1) 237/364 (2) 200/361 (3) 157/356 (4) 102/360	(1)125/364 (2) 90/361 (3) 53/356 (4) 33/360	(1) 174/364 (2) 127/361 (3) 107/365 (4) 64/360	(1) 90/364 (2) 59/361 (3) 37/356 (4) 30/360	From 2 to 24 h (1) 81/364 (2) 115/361 (3) 135/356 (4) 192/360
Brandes 2007 Study 2	(1) suma/naprox 85/500 mg, n = 367 (2) suma 85 mg, n = 370 (3) naprox 500 mg, n = 371 (4) placebo, n = 387	No data	(1) 207/362 (2) 182/362 (3) 158/364 (4) 109/382	(1)107/362 (2) 82/362 (3) 57/364 (4) 37/382	(1) 158/362 (2) 121/362 (3) 102/364 (4) 64/382	(1) 83/362 (2) 51/362 (3) 37/364 (4) 25/382	From 2 to 24 h (1) 83/362 (2) 137/362 (3) 143/364 (4) 223/382
Calhoun 2014	(1) suma/naprox 85/500 mg, n = 43 (2) placebo n = 43	No data	No data	(1) 63.9% (2) 33.3%	No data	(1) 69.1% (2) 23.3%	No data
Lipton 2009 Study 1	(1) suma/naprox 85/500 mg, n = 447 (1693 attacks) (2) placebo, n = 123 (424 attacks)	No data	No data	1st attack: (1) 230/443 (2) 25/123 All attacks: (1) 856/1665 (2) 106/422	No data	1st attack: (1) 168/443 (2) 15/123 All attacks: (1) 608/1665 (2) 72/422	From 2 to 24 h 1st attack: (1) 52/443 (2) 47/123 All attacks: (1) 197/1668 (2) 141/422
Lipton 2009 Study 2	(1) suma/naprox 85/500 mg, n = 458 (1678 attacks) (2) placebo, n = 107 (422 attacks)	No data	No data	1st attack: (1) 236/454 (2) 16/106 All attacks: (1) 833/1655 (2) 83/416	No data	1st attack: (1) 159/455 (2) 12/106 All attacks: (1) 564/1655 (2) 52/416	1st attack: (1) 52/455 (2) 43/106 All attacks: (1) 183/1662 (2) 144/416
Mannix 2009 Study 1	(1) suma/naprox 85/500 mg, n = 152 (2) placebo, n = 160	No data	No data	(1) 63/151 (2) 37/160	No data	(1) 44/151 (2) 29/160	From 2 to 48 h (1) 56/151 (2) 85/160
Mannix 2009 Study 2	(1) suma/naprox 85/500 mg, n = 151 (2) placebo, n = 160	No data	No data	(1) 79/151 (2) 35/159	No data	(1) 57/151 (2) 16/159	From 2 to 48 h (1) 47/151 (2) 110/159
Mathew 2009 Study 1	(1) suma/naprox 85/500 mg, n = 136 (2) placebo, n = 134	No data	No data	(1) 54/136 (2) 23/134	No data	(1) 35/136 (2) 11/134	From 2 to 24 h (1) 39/136 (2) 84/134
Mathew 2009 Study 2	(1) suma/naprox 85/500 mg, n = 134 (2) placebo, n =133	No data	No data	(1) 59/134 (2) 19/133	No data	(1) 42/134 (2) 11/133	From 2 to 24 h (1) 29/134 (2) 73/133
Silberstein 2008 Study 1	(1) suma/naprox 85/500 mg, n = 280 (2) placebo, n = 296	No data	No data	(1) 146/280 (2) 50/296	No data	(1) 126/280 (2) 36/296	From 2 to 24 h (1) 56/280 (2) 139/296
Silberstein 2008 Study 2	(1) suma/naprox 85/500 mg, n = 276 (2) placebo, n = 259	No data	No data	(1) 141/276 (2) 39/259	No data	(1) 110/276 (2) 36/259	From 2 to 24 h (1) 44/276 (2) 117/259
Smith 2005	(1) suma/naprox 50/500 mg, n = 250 (2) suma 50 mg, n = 229 (3) naprox 500 mg, n = 250 (4) placebo, n = 241	(1) 73/250 (2) 52/226 (3) 67/248 (4) 29/241	(1) 163/250 (2) 111/226 (3) 114/248 (4) 65/241	(1) 85/250 (2) 45/226 (3) 45/248 (4) 14/241	(1) 115/250 (2) 66/226 (3) 62/248 (4) 41/241	(1) 63/250 (2) 25/226 (3) 30/248 (4) 12/241	From 2 to 24 h (1) 88/250 (2) 115/226 (3) 129/248 (4) 154/241
TRX109011/132010	(1) suma/naprox 85/500 mg, n = 317 (2) BCM, n = 304 (3) placebo, n = 320	No data	(1) 148/317 (2) 114/304 (3) 76/320	(1) 45/317 (2) 26/304 (3) 16/320	(1) 107/317 (2) 67/304 (3) 45/320	(1) 26/317 (2) 18/304 (3) 10/320	First dose only From 2 to 24 h (possibly 48 h) (1) 52/107 (2) 67/108 (3) 74/103
BCM: butalbital‐containing combination medication (butalbital 50 mg, paracetamol (acetaminophen) 325 mg, and caffeine 40 mg); HR: headache relief; naprox: naproxen; PF: pain‐free; SHR: sustained headache relief; SPF: sustained pain‐free; suma: sumatriptan; suma/naprox: sumatriptan plus naproxen.