Summary of results: relief of associated symptoms at two hours
Intervention	Studies	Attacks with symptom present	Treatment (%)	Control (%)	Risk ratio (95% CI)	NNT (95% CI)
Nausea
Sumatriptan plus naproxen 85/500 mg vs placebo	8	1705	36	10	3.5 (2.8 to 4.3)	3.9 (3.4 to 4.5)
Sumatriptan plus naproxen 85/500 mg vs sumatriptan 85 mg	2	718	39	26	1.5 (1.2 to 1.9)	7.6 (5.0 to 16)
Sumatriptan plus naproxen 85/500 mg vs naproxen 500 mg	2	726	39	36	1.1 (0.90 to 1.3)	not calculated
Photophobia
Sumatriptan plus naproxen 85/500 mg vs placebo	8	3127	53	19	2.8 (2.4 to 3.1)	2.9 (2.7 to 3.2)
Sumatriptan plus naproxen 85/500 mg vs sumatriptan 85 mg	2	1186	43	36	1.2 (1.04 to 1.4)	14 (7.8 to 59)
Sumatriptan plus naproxen 85/500 mg vs naproxen 500 mg	2	1176	43	31	1.4 (1.2 to 1.6)	8.3 (5.7 to 15)
Phonophobia
Sumatriptan plus naproxen 85/500 mg vs placebo	8	2856	54	20	2.6 (2.3 to 3.0)	2.9 (2.6 to 3.2)
Sumatriptan plus naproxen 85/500 mg vs sumatriptan 85 mg	2	1146	48	38	1.3 (1.1 to 1.5)	10 (6.4 to 23)
Sumatriptan plus naproxen 85/500 mg vs naproxen 500 mg	2	1135	48	32	1.5 (1.3 to 1.7)	6.4 (4.7 to 10)
CI: confidence interval; NNT: number needed to treat for an additional beneficial outcome.