Extended Data Figure 1. Summary of cell lines used in this report.

Otx2^lacZ/GFP and Otx2^lacZ/fl ESCs have been described previously. Summarized below are further modifications to Otx2 or Blimp1, or transgene additions in the above or wild-type backgrounds. Further schematic details illustrating the points of Cas9 modification of Otx2 or Blimp1 and genotype verification of derived cell lines are shown in Extended Data Figure 3 or 6, respectively.