Comparison 7. Opioids versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Exercise tolerance	12		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 6MWT: total distance	1	22	Mean Difference (IV, Fixed, 95% CI)	‐28.0 [‐113.58, 57.58]
1.2 6MWT: change from baseline	2	52	Mean Difference (IV, Fixed, 95% CI)	47.78 [35.88, 59.67]
1.3 Workload (watts)	4	70	Mean Difference (IV, Fixed, 95% CI)	‐1.70 [‐3.29, ‐0.10]
1.4 Treadmill distance	2	60	Mean Difference (IV, Fixed, 95% CI)	‐37.64 [‐96.17, 20.88]
1.5 Time on treadmill	3	76	Mean Difference (IV, Fixed, 95% CI)	‐13.42 [‐42.55, 15.70]
1.6 Maximum work cycle	1	24	Mean Difference (IV, Fixed, 95% CI)	‐1.30 [‐1.81, ‐0.79]