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. 2017 Oct 30;2017(10):CD009460. doi: 10.1002/14651858.CD009460.pub2

Comparison 1. Uric acid lowering therapies (UAR) versus placebo/no treatment.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Dialysis 3   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 1 year 1 51 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.07, 15.74]
1.2 2 years 2 218 Risk Ratio (M‐H, Random, 95% CI) 0.40 [0.05, 3.00]
1.3 7 years 1 116 Risk Ratio (M‐H, Random, 95% CI) 0.56 [0.24, 1.30]
2 Serum creatinine 3   Mean Difference (IV, Random, 95% CI) Subtotals only
2.1 4 months 1 40 Mean Difference (IV, Random, 95% CI) ‐26.52 [‐56.78, 3.74]
2.2 1 year 2 83 Mean Difference (IV, Random, 95% CI) ‐73.35 [‐107.28, ‐39.41]
3 eGFR 5   Mean Difference (IV, Random, 95% CI) Subtotals only
3.1 4 months 1 67 Mean Difference (IV, Random, 95% CI) 5.20 [‐1.72, 12.12]
3.2 6 months 3 246 Mean Difference (IV, Random, 95% CI) 4.91 [1.06, 8.76]
3.3 1 year 1 113 Mean Difference (IV, Random, 95% CI) 5.5 [0.59, 10.41]
3.4 2 years 2 164 Mean Difference (IV, Random, 95% CI) 4.00 [‐3.28, 11.28]
3.5 5 years 1 107 Mean Difference (IV, Random, 95% CI) 2.70 [‐2.55, 7.95]
4 Death 4   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
4.1 6 months 2 498 Risk Ratio (M‐H, Random, 95% CI) 1.66 [0.61, 4.48]
4.2 2 years 2 218 Risk Ratio (M‐H, Random, 95% CI) 0.13 [0.02, 1.06]
4.3 7 years 1 113 Risk Ratio (M‐H, Random, 95% CI) 0.88 [0.51, 1.51]
5 Systolic BP 5   Mean Difference (IV, Random, 95% CI) Subtotals only
5.1 1 month 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 3 months 1 100 Mean Difference (IV, Random, 95% CI) 2.0 [‐3.83, 7.83]
5.3 4 months 2 107 Mean Difference (IV, Random, 95% CI) ‐1.22 [‐5.47, 3.04]
5.4 6 months 1 113 Mean Difference (IV, Random, 95% CI) 1.0 [‐5.09, 7.09]
5.5 1 year 2 164 Mean Difference (IV, Random, 95% CI) ‐0.80 [‐7.87, 6.26]
5.6 2 years 1 113 Mean Difference (IV, Random, 95% CI) 1.0 [‐4.17, 6.17]
6 Diastolic BP 5   Mean Difference (IV, Random, 95% CI) Subtotals only
6.1 1 month 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.2 3 months 1 100 Mean Difference (IV, Random, 95% CI) ‐2.0 [‐6.77, 2.77]
6.3 4 months 2 107 Mean Difference (IV, Random, 95% CI) 0.51 [‐3.42, 4.44]
6.4 6 months 1 113 Mean Difference (IV, Random, 95% CI) ‐1.0 [‐4.32, 2.32]
6.5 1 year 2 164 Mean Difference (IV, Random, 95% CI) 0.71 [‐3.94, 5.35]
6.6 2 years 1 113 Mean Difference (IV, Random, 95% CI) ‐1.0 [‐4.69, 2.69]
7 Hospitalisation 2   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
7.1 6 months 1   Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7.2 2 years 1   Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
8 Adverse events 4   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
8.1 Cardiovascular death 1 405 Risk Ratio (M‐H, Random, 95% CI) 1.99 [0.61, 6.50]
8.2 Cardiovascular events 1 113 Risk Ratio (M‐H, Random, 95% CI) 0.46 [0.20, 1.04]
8.3 GI upset 2 206 Risk Ratio (M‐H, Random, 95% CI) 5.12 [0.61, 43.04]
8.4 Heart failure hospitalisation 1 405 Risk Ratio (M‐H, Random, 95% CI) 1.72 [0.94, 3.16]
8.5 Rash 1 51 Risk Ratio (M‐H, Random, 95% CI) 3.12 [0.13, 73.06]
9 C‐reactive protein 3   Mean Difference (IV, Random, 95% CI) Totals not selected
9.1 3 months 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9.2 4 months 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9.3 1 year 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10 Cardiovascular markers 3   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
10.1 E wave velocity 1 53 Std. Mean Difference (IV, Random, 95% CI) ‐0.13 [‐0.67, 0.41]
10.2 E‐E' 1 53 Std. Mean Difference (IV, Random, 95% CI) 0.11 [‐0.43, 0.65]
10.3 Flow‐mediated dilatation 2 167 Std. Mean Difference (IV, Random, 95% CI) 1.79 [‐1.17, 4.75]
10.4 Nitrate‐induced dilatation 1 100 Std. Mean Difference (IV, Random, 95% CI) 1.02 [0.60, 1.43]
10.5 NT‐proBNP 1 53 Std. Mean Difference (IV, Random, 95% CI) 0.15 [‐0.39, 0.69]
11 Proteinuria 4 147 Mean Difference (IV, Random, 95% CI) ‐0.08 [‐0.59, 0.43]
11.1 4 months 1 40 Mean Difference (IV, Random, 95% CI) ‐0.60 [‐1.16, ‐0.04]
11.2 6 months 1 40 Mean Difference (IV, Random, 95% CI) 0.05 [‐0.57, 0.67]
11.3 1 year 1 51 Mean Difference (IV, Random, 95% CI) 0.37 [‐1.67, 2.41]
11.4 2 years 1 16 Mean Difference (IV, Random, 95% CI) 0.42 [‐0.40, 1.24]
12 Uric acid 8   Mean Difference (IV, Random, 95% CI) Subtotals only
12.1 3 months 1 100 Mean Difference (IV, Random, 95% CI) ‐196.28 [‐211.83, ‐180.73]
12.2 4 months 1 67 Mean Difference (IV, Random, 95% CI) ‐83.28 [‐111.59, ‐54.97]
12.3 6 months 3 246 Mean Difference (IV, Random, 95% CI) ‐100.73 [‐166.80, ‐34.65]
12.4 1 year 4 253 Mean Difference (IV, Random, 95% CI) ‐173.88 [‐268.42, ‐79.35]
12.5 2 years 2 163 Mean Difference (IV, Random, 95% CI) ‐89.49 [‐115.62, ‐63.36]