Depletion of CD151 diminishes acute retention of MDA-MB-231 in the lung vascular bed. BCECF – labelled CD151-positive and CD151-negative MDA-MB-231 were introduced via the carotid artery into anaesthetised mice and monitored intravitally. Numbers adherent within the hepatic sinusoidal and pulmonary capillaries were quantified in 7 and 10 random static fields of view, respectively. A. Shown photographs of representative fields. Note, a significant reduction in recruitment of labelled CD151-negative MDA-MB-231 cells in the lungs (right panel) as compared to the control, MDA-MB-231/CD151(+) cells (left panel). B. Quantification of the results from 5 independent experiments. Note, depletion of CD151 decreased retention of the cells in the lungs (top histogram) but not within the liver (bottom histogram). Error bars, SEM.