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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: Cancer Res. 2010 Jun 22;70(14):6059–6070. doi: 10.1158/0008-5472.CAN-09-3497

Figure 5.

Figure 5

Depletion of CD151 diminishes acute retention of MDA-MB-231 in the lung vascular bed. BCECF – labelled CD151-positive and CD151-negative MDA-MB-231 were introduced via the carotid artery into anaesthetised mice and monitored intravitally. Numbers adherent within the hepatic sinusoidal and pulmonary capillaries were quantified in 7 and 10 random static fields of view, respectively. A. Shown photographs of representative fields. Note, a significant reduction in recruitment of labelled CD151-negative MDA-MB-231 cells in the lungs (right panel) as compared to the control, MDA-MB-231/CD151(+) cells (left panel). B. Quantification of the results from 5 independent experiments. Note, depletion of CD151 decreased retention of the cells in the lungs (top histogram) but not within the liver (bottom histogram). Error bars, SEM.